|Title:||Molecular mechanisms of etoposide|
|Abstract:||Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms. In this review we will focus on molecular mechanisms that account for the biological effect of etoposide.|
|Appears in Collections:||Review Articles|
Files in This Item:
|Montecucco_19012015_proof.pdf||DNB||180.45 kB||Adobe PDF||View/Open|
This item is protected by original copyright
All resources in the repository are protected by copyright.