Authors: Russo, Patrizia
Del Bufalo, Alessandra
Fini, Massimo
Title: Deep sea as a source of novel-anticancer drugs
Other Titles: Update on discovery and preclinical/clinical evaluation in a systems medicine perspective
Language (ISO): en
Abstract: The deep-sea habitat is a source of very potent marine-derived agents that may inhibit the growth of human cancer cells “in vitro” and “in vivo”. Salinosporamide-A, Marizomib, by Salinispora species is a proteasome inhibitor with promising anticancer activity (Phase I/II trials). Different deep-sea-derived drugs are under preclinical evaluation. Cancer is a complex disease that may be represented by network medicine. A simple consequence is the change of the concept of target entity from a single protein to a whole molecular pathway and or cellular network. Deep-sea-derived drugs fit well to this new concept.
Subject Headings: deep-sea-derived drugs
systems medicine
preclinical studies
clinical studies
Issue Date: 2015-02-10
Appears in Collections:Review Articles

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