Authors: | Russo, Patrizia Del Bufalo, Alessandra Fini, Massimo |
Title: | Deep sea as a source of novel-anticancer drugs |
Other Titles: | Update on discovery and preclinical/clinical evaluation in a systems medicine perspective |
Language (ISO): | en |
Abstract: | The deep-sea habitat is a source of very potent marine-derived agents that may inhibit the growth of human cancer cells “in vitro” and “in vivo”. Salinosporamide-A, Marizomib, by Salinispora species is a proteasome inhibitor with promising anticancer activity (Phase I/II trials). Different deep-sea-derived drugs are under preclinical evaluation. Cancer is a complex disease that may be represented by network medicine. A simple consequence is the change of the concept of target entity from a single protein to a whole molecular pathway and or cellular network. Deep-sea-derived drugs fit well to this new concept. |
Subject Headings: | deep-sea-derived drugs cancer systems medicine network therapy preclinical studies clinical studies |
URI: | http://hdl.handle.net/2003/34057 http://dx.doi.org/10.17877/DE290R-7879 |
Issue Date: | 2015-02-10 |
Appears in Collections: | Review Articles |
Files in This Item:
File | Description | Size | Format | |
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Russo_10022015_proof.pdf | DNB | 141.79 kB | Adobe PDF | View/Open |
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