Authors: Muttaqillah, Najihan Abdul Samat
Abdul Wahab, Asrul
Ding, Chuan Hun
Mohammad, Marlyn
Biswas, Suvra
Rahman, Md. Mostafizur
Title: Presence of anti-mitochondrial antibodies and elevated serum immunoglobulin G levels
Other Titles: Is this primary biliary cirrhosis-autoimmune hepatitis overlap syndrome?
Language (ISO): en
Abstract: Primary biliary cirrhosis in combination with autoimmune hepatitis has been termed “overlap syndrome”, but its diagnosis is challenging. We report a case of a 43-year-old lady who presented with a six-month history of jaundice and pruritus. She subsequently developed gum bleeds. Laboratory investigations revealed hypochromic microcytic anemia, abnormal coagulation profiles, elevated serum alanine transferase and alkaline phosphatase levels, and raised serum IgG and IgM levels. Her serum was also positive for anti-nuclear and anti-mitochondrial antibodies. The findings from her abdominal CT scan were suggestive of early liver cirrhosis and the histopathological examination results of her liver biopsy were consistent with primary biliary cirrhosis. The patient was treated with ursodeoxycholic acid and her liver function test parameters normalized after six months.
Subject Headings: autoimmune hepatitis
anti-mitochondrial antibody
anti-nuclear antibody
overlap syndrome
primary biliary cirrhosis
Issue Date: 2015-01-30
Appears in Collections:Case Reports

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