Full metadata record
DC FieldValueLanguage
dc.contributor.authorGuh, Ying-Jey-
dc.contributor.authorLin, Chia-Hao-
dc.contributor.authorHwang, Pung-Pung-
dc.date.accessioned2016-05-20T09:12:19Z-
dc.date.available2016-05-20T09:12:19Z-
dc.date.issued2015-05-11-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/34993-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17041-
dc.description.abstractFish, like mammals, have to maintain their body fluid ionic and osmotic homeostasis through sophisticated iono-/osmoregulation mechanisms, which are conducted mainly by ionocytes of the gill (the skin in embryonic stages), instead of the renal tubular cells in mammals. Given the advantages in terms of genetic database availability and manipulation, zebrafish is an emerging model for research into regulatory and integrative physiology. At least five types of ionocytes, HR, NaR, NCC, SLC26, and KS cells, have been identified to carry out Na+ uptake/H+ secretion/NH4+ excretion, Ca2+ uptake, Na+/Cl- uptake, K+ secretion, and Cl- uptake/HCO3- secretion, respectively, through distinct sets of transporters. Several hormones, namely isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyorid hormone 1, catecholamines, and the renin-angiotensin-system, have been demonstrated to positively or negatively regulate ion transport through specific receptors at different ionocytes stages, at either the transcriptional/translational or posttranslational level. The knowledge obtained using zebrafish answered many long-term contentious or unknown issues in the field of fish iono-/osmoregulation. The homology of ion transport pathways and hormone systems also means that the zebrafish model informs studies on mammals or other animal species, thereby providing insights into related fields.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 14, 2015en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectosmoregulationen
dc.subjection regulationen
dc.subjectionocyteen
dc.subjecthormoneen
dc.subjectzebrafishen
dc.subject.ddc610-
dc.titleOsmoregulation in zebrafish: ion transport mechanisms and functional regulationen
dc.typeText-
dc.identifier.doi10.17179/excli2015-246-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
Appears in Collections:Review Articles

Files in This Item:
File Description SizeFormat 
Hwang_11052015_proof.pdfDNB892.83 kBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons