Authors: Ham, Young Min
Yoon, Weon-Jong
Lee, Wook Jae
Kim, Sang-Cheol
Baik, Jong Seok
Kim, Jin Hwa
Lee, Geun Soo
Lee, Nam Ho
Hyun, Chang-Gu
Title: Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum
Language (ISO): en
Abstract: During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.
Subject Headings: brown alga
isoketochabrolic acid
Sargassum micracanthum
Issue Date: 2015-10-15
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