Authors: | Phopin, Kamonrat Sinthupoom, Nujarin Treeratanapiboon, Lertyot Kunwittaya, Sarun Prachayasittikul, Supaluk Ruchirawat, Somsak Prachayasittikul, Virapong |
Title: | Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes |
Language (ISO): | en |
Abstract: | 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents. |
Subject Headings: | aminoquinoline metal complexes uracils antimicrobial antimalarial |
URI: | http://hdl.handle.net/2003/35089 http://dx.doi.org/10.17877/DE290R-17137 |
Issue Date: | 2016-02-18 |
Rights link: | http://creativecommons.org/licenses/by/4.0 |
Appears in Collections: | Original Articles |
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