Authors: Karker, Manel
Falleh, Hanen
Msaada, Kamel
Smaoui, Abderrazak
Abdelly, Chedly
Legault, Jean
Ksouri, Riadh
Title: Antioxidant, anti-inflammatory and anticancer activities of the medicinal halophyte Reaumuria vermiculata
Language (ISO): en
Abstract: Reaumuria vermiculata is a xero-halophytic specie widely distributed in the south of Tunisia. In the current study, antioxidant, anti-inflammatory and anticancer activities of Reaumuria vermiculata shoot extracts as well as its phenolic compounds were investigated in different solvent extracts (hexane, dichloromethane, methanol and water). Results showed a strong antioxidant activity, using the ORAC method and a cell based-assay, in methanol extract as well as an important phenolic composition (117.12 mg GAE/g). Hexane and dichloromethane proved an interesting anticancer activity against A-549 lung carcinoma cells, with IC50 values of 17 and 23 μg/ml, respectively. Besides, dichloromethane extract displayed the utmost anti-inflammatory activity, inhibiting NO release over 100 % at 80 μg /ml in LPS-stimulated RAW 264.7. Taken together, these finding suggest that R. vermiculata exhibited an interesting biological activities which may be related to the phenolic composition of this plant. Moreover, the identification of phenolic compounds in R. vermiculata dichloromethane extract using RP-HPLC revealed that myricetin was the major molecule. These results allow us to propose R. vermiculata as a valuable source for bioactive and natural compounds exhibiting interesting biological capacities.
Subject Headings: Reaumuria vermiculata
phenolic compounds
antioxidant activity
anti-inflammatory
anticancer
RP-HPLC
URI: http://hdl.handle.net/2003/35109
http://dx.doi.org/10.17877/DE290R-17157
Issue Date: 2016-04-25
Appears in Collections:Original Articles

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