Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ko, Eun-Yi | - |
dc.contributor.author | Yoon, Weon-Jong | - |
dc.contributor.author | Lee, Hae-Won | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Ko, Young-Hwan | - |
dc.contributor.author | Fernando, I.P. Shanura | - |
dc.contributor.author | Cho, Kichul | - |
dc.contributor.author | Lee, Chi-Heon | - |
dc.contributor.author | Hur, Sung-Pyo | - |
dc.contributor.author | Cho, Su-Hyeon | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Kim, Daekyung | - |
dc.contributor.author | Kim, Kil-Nam | - |
dc.date.accessioned | 2016-11-24T15:05:59Z | - |
dc.date.available | 2016-11-24T15:05:59Z | - |
dc.date.issued | 2016-06-28 | - |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | http://hdl.handle.net/2003/35618 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-17659 | - |
dc.description.abstract | The anti-inflammatory properties of the supercritical fluid extract of Ishige okamurae (SFEIO) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. The lipid profile of the SFEIO, reviled the presence of palmitic acid (220.2 mg/g), linoleic acid (168.0 mg/g), and oleic acid (123.0 mg/g). SFEIO was found to exert it’s anti-inflammatory effects through inhibiting nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 production in LPS-stimulated RAW 264.7 cells, without inducing cytotoxicity. SFEIO did not effect on the LPS-induced p38 kinase phosphorylation, whereas it attenuated the extracellular-related signaling kinase (ERK) and c-Jun N-terminal kinase (JNK) phosphorylation. Furthermore, SFEIO inhibited the LPS-induced IκB-α degradation and p50 NF-κB activation. These results suggest that SFEIO exerts its anti-inflammatory effects in LPS-activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-κB. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal;Vol. 15, 2016 | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | supercritical fluid extraction | en |
dc.subject | linoleic acid | en |
dc.subject | Ishige okamurae | en |
dc.subject | anti-inflammatory | en |
dc.subject | NF- κB | en |
dc.subject.ddc | 610 | - |
dc.title | Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae | en |
dc.type | Text | - |
dc.identifier.doi | 10.17179/excli2016-337 | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Appears in Collections: | Original Articles |
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Kim_Kim_28062016_proof.pdf | DNB | 1.06 MB | Adobe PDF | View/Open |
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