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dc.contributor.authorXu, Lihua-
dc.contributor.authorGuo, Yang-
dc.contributor.authorYan, Wenying-
dc.contributor.authorCen, Jiannong-
dc.contributor.authorNiu, Yuna-
dc.contributor.authorYan, Qing-
dc.contributor.authorHe, Hailong-
dc.contributor.authorChen, Chien-Shing-
dc.contributor.authorHu, Shaoyan-
dc.date.accessioned2017-08-25T08:46:44Z-
dc.date.available2017-08-25T08:46:44Z-
dc.date.issued2017-03-07-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/36065-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18081-
dc.description.abstractDifferential expression of microRNAs (miRNAs) has been implicated in leukemogenesis. We investigate the ex- pression pattern of miR-196b. Using quantitative real-time PCR (qRT-PCR), we detected the expression of miR- 196b and its correlated genes (SMC1A/MLH1) in initial pediatric AML. A significant association was observed between overexpression of miR-196b and inferior overall survival of pediatric AML (Log Rank P<0.0001). AML M4/5 subtype, high white blood cell (WBC) count at presentation, MLL rearrangement, or FLT3-ITD mutation at diagnosis and non-remission group after the first induction chemotherapy possessed higher miR-196b expression. Furthermore, a positive relationship was found between the expression of miR-196b and SMC1A/MLH1 (Spear- man’s r=0.37 and 0.44, P=0.001 and <0.0001, respectively). Taken together, these findings suggest that differen- tially high expression of miR-196b in diagnostic marrow samples of pediatric AML is associated with unfavorable outcome, and miR-196b potentially can be a novel biomarker for the diagnosis, prognosis and treatment in pediatric AML.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectmiR-196ben
dc.subjectAMLen
dc.subjectpediatric/childen
dc.subjectbiomarkeren
dc.subject.ddc610-
dc.titleHigh level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcomeen
dc.typeText-
dc.identifier.doi10.17179/excli2016-707-
dc.identifier.doi10.17179/excli2016-707-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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