Authors: Xu, Dongliang
Wang, Xingjie
Jiang, Chenyi
Ruan, Yuan
Xia, Shujie
Wang, Xiaohai
Title: The androgen receptor plays different roles in macrophage-induced proliferation in prostate stromal cells between transitional and peripheral zones of benign prostatic hypertrophy
Language (ISO): en
Abstract: Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate via the androgen receptor (AR)/inflammatory cytokine CCL3-dependent pathway. In our present study, we used the co-culture system of human macrophages and various prostatic zone stromal cells to further demonstrate that infiltrating macrophages promote prostatic stromal cell proliferation through stromal AR-dependent pathways, and we show that the stroma of TZ and PZ respond to macrophages differently because of differences in stromal AR signaling; this could possibly be one of the key pathways for stromal expansion during BPH development and progression. We hypothesize that AR and different downstream inflammatory mediators between TZ and PZ could serve as potential targets for the future design of therapeutic agents for BPH and our results provide significant insights into the search for targeted therapeutic approaches to battle BPH.
Subject Headings: stromal cell
macrophage
androgen receptor
benign prostatic hyperplasia
transitional zone
URI: http://hdl.handle.net/2003/36198
http://dx.doi.org/10.17877/DE290R-18212
Issue Date: 2017-06-22
Appears in Collections:Original Articles

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