Authors: Gargouri, Manel
Soussi, Ahlem
Akrouti, Amel
Magné, Christian
El Feki, Abdelfattah
Title: Ameliorative effects of Spirulina platensis against lead-induced nephrotoxicity in newborn rats
Other Titles: modulation of oxidative stress and histopathological changes
Language (ISO): en
Abstract: Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplemen- tation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were ran- domly divided into four groups: group I (control) was given a normal diet, group II (positive control, S) received a diet enriched with spirulina, group III received only lead through drinking water (Pb), and group IV received both a diet enriched with spirulina and lead contaminated water (S Pb). The treatment of pregnant rats with lead administrated in drinking water, from the 5th day of pregnancy until day 14 after delivery, induced an increased level of renal lipid peroxidation, protein carbonyl, hydrogen peroxide and advanced oxidation protein product, a decreased renal content of glutathione and antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase in newborns. A statistically significant increase of renal DNA, mRNA, hematological parameters as well as in plasma urea and creatinine serum levels and lactate dehydrogenase was seen in pups, while those of uric acid declined. Interestingly, these biochemical modifications were accompanied by a significant decrease of lactate dehydrogenase in kidney, plasma alkaline phosphatase and gamma glutamyl-transpeptidase levels, urinary levels of creatinine and urea. Conversely, supplementation of lead-treated mother’s with spirulina alleviated hematotoxicity induced by lead as evidenced, by restoring the biochemical markers cited above to near normal levels. Nevertheless, the distorted histoarchitecture in rat kidney attenuated following spirulina supple- mentation. It can be then concluded that spirulina is an important protective source against kidney impairments.
Subject Headings: Antioxidant activities
DNA and mRNA damage
Neonate rats
Oxidative stress
Spirulina supplementation
Issue Date: 2018-03-02
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