Authors: Sangkyun, Lee
Schramm, Alexander
Title: Preprocessing of Affymetrix Exon Expression Arrays
Language (ISO): en
Abstract: The activity of genes can be captured by measuring the amount of messenger RNAs transcribed from the genes, or from their subunits called exons. In our study, we use the Affymetrix Human Exon ST v1.0 micro arrays to measure the activity of exon s in Neuroblastoma cancer patients. The purpose is to discover a small number of genes or exons that play important roles in differentiating high - risk patients fro m low - risk counterparts. Although the technology has been improved for the past 15 years, array measurements still can be contaminated by various factors, including human error. Since the number of arrays is often only few hundreds, atypical errors can hardly be canceled by large numbers of normal arrays. In this article we describe how we filter out low - quality arrays in a principled way, so that we can obtain more reliable results in downstream analyses.
Issue Date: 2013-03
Appears in Collections:Sonderforschungsbereich (SFB) 876

Files in This Item:
File Description SizeFormat 
lee_schramm_2013a.pdfDNB2.82 MBAdobe PDFView/Open

This item is protected by original copyright

All resources in the repository are protected by copyright.