Authors: | Zhou, Ying Sun, Mingfang |
Title: | A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis |
Language (ISO): | en |
Abstract: | The present meta-analysis aimed to evaluate the relationship between body mass index (BMI) and rheumatoid arthritis (RA). A systematic search of the Cochrane, Pubmed, and Embase databases was conducted to identify relevant studies published before September 2017 using terms related to BMI and RA. Fixed or random-effect models were used to estimate the pooled relative risk (RR) with 95 % confidence interval (CI). Subgroup analyses by sex were performed to investigate the association between BMI and RA in male and female subgroups. A total of 14 eligible studies containing 353,948 patients were included in the analysis. The pooled results suggested that the odds ratios (ORs) of RA were 1.08 (95 % CI: 1.00~1.15) for overweight, and 1.32 (95 % CI: 1.11~1.54) for obesity, respectively, suggesting that a higher BMI increases the risk of RA compared to normal weight. Further subgroup analyses showed a positive association between BMI and RA risk but only in females, with a RR of 1.11 (95 % CI: 1.00~1.22) for overweight and 1.40 (95 % CI: 1.24~1.57) for obesity. In conclusion, an increased BMI may lead to a higher risk for RA development. Furthermore, the positive association between BMI and RA risk may be stronger in female populations than in males. However, additional analyses are needed. |
Subject Headings: | Rheumatoid arthritis (RA) Body mass index (BMI) Meta-analysis Risk factor |
URI: | http://hdl.handle.net/2003/37976 http://dx.doi.org/10.17877/DE290R-19961 |
Issue Date: | 2018-11-06 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Sun_06112018_proof.pdf | DNB | 571.12 kB | Adobe PDF | View/Open |
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