Authors: Rodríguez-Pérez, José Manuel
Posadas-Sánchez, Rosalinda
Blachman-Braun, Ruben
Vargas-Alarcón, Gilberto
Posadas-Romero, Carlos
García-Flores, Esbeidy
López-Bautista, Fabiola
Tovilla-Zárate, Carlos Alfonso
González-Castro, Thelma Beatriz
Borgonio-Cuadra, Verónica Marusa
Pérez-Hernández, Nonanzit
Title: A haplotype of the phosphodiesterase 4D (PDE4D) gene is associated with myocardial infarction and with cardiometabolic parameters
Other Titles: the GEA study
Language (ISO): en
Abstract: The phosphodiesterase family is involved in a wide spectrum of diseases, including ischemic stroke. However, few studies have analyzed the relationship between phosphodiesterase 4D (PDE4D) and myocardial infarction (MI). Therefore, the aim of this research was to evaluate the association of the PDE4D gene polymorphisms with MI, and with cardiometabolic parameters in the Mexican population. Six polymorphisms (rs2910829, rs1423246, rs966221, rs4502776, rs13172481, and rs6869495) were genotyped in 1023 MI patients and 1105 healthy controls. A similar distribution of the six polymorphisms was observed in both studied groups. However, after evaluating the linkage disequilibrium, we detected a risk haplotype for MI (AGAGAA; OR = 1.148; P = 0.025). In addition, the polymorphisms were associated with the presence of some clinical and metabolic parameters (central obesity, hypertriglyceridemia, Aspartate transaminase >p75, Lipoprotein (a) >30 mg/dL, TAT >p75, fatty liver, and vitamin D <30 ng/dL) in healthy controls. The results suggest that in the Mexican population, a PDE4D haplotype is associated with increased risk of developing MI, and that PDE4D polymorphisms are independently associated with the presence of cardiometabolic parameters.
Subject Headings: Phosphodiesterase
Myocardial infarction
Mexican population
Issue Date: 2018-12-19
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