Full metadata record
DC FieldValueLanguage
dc.contributor.authorYousefzadeh, Nasibeh-
dc.contributor.authorKashfi, Khosrow-
dc.contributor.authorJeddi, Sajad-
dc.contributor.authorGhasemi, Asghar-
dc.date.accessioned2020-05-19T06:54:51Z-
dc.date.available2020-05-19T06:54:51Z-
dc.date.issued2020-01-10-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/39105-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21023-
dc.description.abstractOsteoporosis affects about 200 million people worldwide and is a silent disease until a fracture occurs. Management of osteoporosis is still a challenge that warrants further studies for establishing new prevention strategies and more effective treatment modalities. For this purpose, animal models of osteoporosis are appropriate tools, of which the ovariectomized rat model is the most commonly used. The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of OVX, (3) selection of an appropriate surgical method and verification of OVX, and (4) evaluation of OVX-induced osteoporosis. This review of literature shows that (i) Sprague-Dawley and Wistar rats are the most common strains used, both responding similarly to OVX; (ii) six months of age appears to be the best time for inducing OVX; (iii) dorsolateral skin incision is an appropriate choice for initiating OVX; and (iv) the success of OVX can be verified 1-3 weeks after surgery, following cessation of the regular estrus cycles, decreased estradiol, progesterone, and uterine weight as well as increased LH and FSH levels. Current data shows that the responses of trabecular bones of proximal tibia, lumbar vertebrae and femur to OVX are similar to those in humans; however, for short-term studies, proximal tibia is recommended. Osteoporosis in rats is verified by lower bone mineral density and lower trabecular number and thickness as well as higher trabecular separation, changes that are observed at 14, 30, and 60 days post-OVX in proximal tibia, lumbar vertebrae and femur, respectively.en
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal;Vol. 19 2020-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAnimal modelen
dc.subjectBoneen
dc.subjectOsteoporosisen
dc.subjectOvariectomyen
dc.subjectRaten
dc.subject.ddc610-
dc.titleOvariectomized rat model of osteoporosisen
dc.title.alternativea practical guideen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
eldorado.dnb.zdberstkatidtrue-
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primaryidentifierhttp://dx.doi.org/10.17179/excli2019-1990de
Appears in Collections:Review Articles 2020

Files in This Item:
File Description SizeFormat 
Jeddi_10012020_proof.pdfDNB388.23 kBAdobe PDFView/Open


This item is protected by original copyright



All resources in the repository are protected by copyright.