Authors: Ahmad, Faiz
Sarder, Amit
Gour, Rajesh
Karna, Shibendra Kumar Lal
Arora, Priya
Kartha, P. Ravindranathan
Pokharel, Yuba Raj
Title: Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway
Language (ISO): en
Abstract: Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells, which is the second leading cause of death globally. To treat cancer, currently, a number of anticancer drugs belonging to various classes chemically are available. The discovery of artemisinin and its derivatives such as artesunate, arteether, and artemether became a milestone in the cure for malaria. Here, we report the anti-cancer property of anhydrodihydroartemisinin (ADHA) - a semisynthetic derivative of artemisinin against prostate cancer cell line PC-3. ADHA was found to be inhibiting growth of PC-3 cells. ADHA was also found to be inhibiting migration of PC-3 cells. At molecular level, ADHA was found to be inhibiting the expression of c-Jun, p-c-Jun, p-Akt and NF-κB and activated caspase 3 and 7. The results show that ADHA like few other artemisinin derivatives hold potential to be used as an anti-cancer agent against prostate cancer cells.
Subject Headings: Anhydrodihydroartemisinin
Caspase 3
Caspase 7
Issue Date: 2020-05-11
Provenance: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Appears in Collections:Original Articles 2020

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