Authors: | Ahmad, Faiz Sarder, Amit Gour, Rajesh Karna, Shibendra Kumar Lal Arora, Priya Kartha, P. Ravindranathan Pokharel, Yuba Raj |
Title: | Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway |
Language (ISO): | en |
Abstract: | Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells, which is the second leading cause of death globally. To treat cancer, currently, a number of anticancer drugs belonging to various classes chemically are available. The discovery of artemisinin and its derivatives such as artesunate, arteether, and artemether became a milestone in the cure for malaria. Here, we report the anti-cancer property of anhydrodihydroartemisinin (ADHA) - a semisynthetic derivative of artemisinin against prostate cancer cell line PC-3. ADHA was found to be inhibiting growth of PC-3 cells. ADHA was also found to be inhibiting migration of PC-3 cells. At molecular level, ADHA was found to be inhibiting the expression of c-Jun, p-c-Jun, p-Akt and NF-κB and activated caspase 3 and 7. The results show that ADHA like few other artemisinin derivatives hold potential to be used as an anti-cancer agent against prostate cancer cells. |
Subject Headings: | Anhydrodihydroartemisinin PC-3 Apoptosis Caspase 3 Caspase 7 c-Jun Akt NF-κB |
URI: | http://hdl.handle.net/2003/39852 http://dx.doi.org/10.17877/DE290R-21743 |
Issue Date: | 2020-05-11 |
Provenance: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
Citation: | https://www.excli.de/index.php/excli/article/view/2290 |
Appears in Collections: | Original Articles 2020 |
Files in This Item:
File | Description | Size | Format | |
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Pokharel_11052020_proof.pdf | DNB | 387.94 kB | Adobe PDF | View/Open |
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