Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ye, Xiaofeng | - |
dc.contributor.author | Kong, Wen | - |
dc.contributor.author | Zafar, Mohammad Ishraq | - |
dc.contributor.author | Zeng, Junchao | - |
dc.contributor.author | Yang, Rui | - |
dc.contributor.author | Chen, Lu-Lu | - |
dc.date.accessioned | 2020-12-14T13:42:26Z | - |
dc.date.available | 2020-12-14T13:42:26Z | - |
dc.date.issued | 2020-08-20 | - |
dc.identifier.citation | Ye, X., Kong, W., Zafar, M. I., Zeng, J., Yang, R. ., & Chen, L.-L. (2020). Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction. EXCLI Journal, 19. 2020, 186-1195. https://doi.org/10.17179/excli2020-2647 | en |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | http://hdl.handle.net/2003/39886 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-21777 | - |
dc.description.abstract | Vascular endothelial growth factor B (VEGF-B) is a critical metabolic regulator in insulin resistance, and lipid distribution. We intended to ascertain the relationship between circulating VEGF-B and non-alcoholic fatty liver disease (NAFLD) in the general public. We recruited a total of 194 general participants for a routine physical health examination; of these, 84 participants were identified with NAFLD and 110 without NAFLD based on ultrasonographic findings. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), HbA1c, liver function, kidney function, plasma VEGF-B levels and indexes of metabolic syndrome (blood pressure, fasting plasma glucose, fasting lipids) were evaluated. Plasma VEGF-B values were significantly higher in individuals with NAFLD compared to those without NAFLD (P = 0.022), and analysis of covariance confirmed this result. VEGF-B showed a positive correlation with γ-glutamyl transpeptidase (γ-GT) and HOMA-IR in univariate analysis (q = 0.242; P = 0.001; q =0.174; P = 0.019, respectively). Multiple linear regression analysis showed that γ-GT and ALT were independently correlated with VEGF-B even after adjusted for gender and age (q = 0.286; P = 0.01; q =0.237; P = 0.033, respectively). Moreover, plasma VEGF-B showed a powerful correlation with blood pressure and renal dysfunction. Plasma VEGF-B might be a new clinical variable related to NAFLD and could be a proper biomarker for the early detection of hypertension and renal dysfunction. However, further studies with large cohorts’ size are warranted to validate our findings. | en |
dc.language.iso | en | - |
dc.publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund | de |
dc.relation.ispartofseries | EXCLI Journal;Vol. 19. 2020, 1186-1195 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Vascular endothelial growth factor B | en |
dc.subject | Non-alcoholic fatty liver disease | en |
dc.subject | Blood pressure | en |
dc.subject | Renal dysfunction | en |
dc.subject | Metabolism | en |
dc.subject.ddc | 610 | - |
dc.title | Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
eldorado.identifier.url | https://doi.org/10.17179/excli2020-2647 | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
eldorado.secondarypublication | true | - |
Appears in Collections: | Original Articles 2020 |
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excli2020-2647.pdf | DNB | 241.85 kB | Adobe PDF | View/Open |
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