Authors: Ralli, Massimo
Campo, Flaminia
Angeletti, Diletta
Minni, Antonio
Artico, Marco
Greco, Antonio
Polimeni, Antonella
de Vincentiis, Marco
Title: Pathophysiology and therapy of systemic vasculitides
Language (ISO): en
Abstract: Systemic vasculitides represent uncommon conditions characterized by the inflammation of blood vessels that can lead to different complex disorders limited to one organ or potentially involving multiple organs and systems. Systemic vasculitides are classified according to the diameter of the vessel that they mainly affect (small, medium, large, or variable). The pathogenetic mechanisms of systemic vasculitides are still partly unknown, as well as their genetic basis. For most of the primary systemic vasculitides, a single gold standard test is not available, and diagnosis is often made after having ruled out other mimicking conditions. Current research has focused on new management protocol and therapeutic strategies aimed at improving long-term patient outcomes and avoiding progression to multiorgan failure with irreversible damage. In this narrative review, authors describe different forms of systemic vasculitides through a review of the literature, with the aim of highlighting the current knowledge and recent findings on etiopathogenesis, diagnosis and therapy.
Subject Headings: Systemic vasculitides
Kawasaki disease
Takayasu arteritis
Polyarteritis nodosa
Giant cell arteritis
Behcet’s disease
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Issue Date: 2020-06-18
Rights link:
Provenance: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Citation: Ralli, M., Campo, F., Angeletti, D., Minni, A., Artico, M., Greco, A., Polimeni, A., & de Vincentiis, M. (2020). Pathophysiology and therapy of systemic vasculitides. EXCLI Journal, 19, 817-854.
Appears in Collections:Review Articles 2020

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