The association of a genetic variant in CDKN2A/B gene and the risk of colorectal cancer

dc.contributor.authorRahmani, Farzad
dc.contributor.authorAvan, Amir
dc.contributor.authorAmerizadeh, Forouzan
dc.contributor.authorFerns, Gordon A.
dc.contributor.authorTalebian, Sahar
dc.contributor.authorShahidsales, Soodabeh
dc.date.accessioned2020-12-14T15:09:09Z
dc.date.available2020-12-14T15:09:09Z
dc.date.issued2020-09-14
dc.description.abstractColorectal cancer is among the most aggressive tumors, and its development involves an interplay between various genetic and environmental familial risk factors. Several genetic polymorphisms have been reported to be associated with colorectal cancer in recent studies. In this current study, we aimed to evaluate the possible relationship between a CDKN2A/B, single nucleotide polymorphisms (SNP) (rs10811661), with the risk of colorectal cancer. A total of 541 individuals with, or without cancer were recruited. DNA was extracted, and genotyped using a Taq-Man based realā€time PCR method. The rs10811661 SNP was associated with an increased risk of colorectal cancer (additive model: OR=3.46, CI= 1.79-6.69, p<0.0001 and recessive model: 5.72, CI= 3.12-10.49, p<0.0001). The distribution of minor alleles in the total population for homozygote allele was 9.2 %, while this was 20.1 % for heterozygotes. In summary, our findings indicate that the rs10811661 polymorphism of the CDKN2A/B gene was strongly related to the occurrence of colorectal cancer suggesting its potential role as a prognostic biomarker for the management of colorectal cancer.en
dc.identifier.citationRahmani, F., Avan, A., Amerizadeh, F., Ferns, G. A., Talebian, S., & Shahidsales, S. (2020). The association of a genetic variant in CDKN2A/B gene and the risk of colorectal cancer. EXCLI Journal, 19, 1316-1321. https://doi.org/10.17179/excli2020-2051de
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39894
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21784
dc.language.isoen
dc.publisherIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmundde
dc.relation.ispartofseriesEXCLI Journal;Vol. 19. 2020, pp.1316-1321
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectColorectal canceren
dc.subjectCDKN2A/Ben
dc.subjectPolymorphismen
dc.subject.ddc610
dc.titleThe association of a genetic variant in CDKN2A/B gene and the risk of colorectal canceren
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.identifier.urlhttps://www.excli.de/index.php/excli/article/view/2051
eldorado.secondarypublicationtrue

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