Susceptible Amino Acid Pairs in Variants in Human Collagen alpha1(III) Chain Precursor

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dc.contributor.authorWu, Guangde
dc.contributor.authorYan, Shaominde
dc.date.accessioned2008-06-17T13:45:52Z
dc.date.available2008-06-17T13:45:52Z
dc.date.issued2004-05-28de
dc.description.abstractIn a previous study we presented a technique to differentiate between randomly predictable and randomly unpredictable amino acid pairs. We have shown that all of 95 variants in human collagen alpha1(I) chain precursor (CA11) occurred at randomly unpredictable amino acid pairs. To study whether this is unique for the human collagen alpha1(I) chain precursor (CA11) or whether this is a more general principle we examined another human collagen precursor, the human collagen alpha1(III) chain precursor (CA13), in which 106 variants have been documented. Interestingly, all of 106 variants occurred at randomly unpredictable amino acid pairs in human CA13. In conclusion, the observation that randomly unpredictable amino acid pairs are more susceptible to variation seems to be a more general principle for human collagen chain precursor proteins.en
dc.identifier.issn1611-2156de
dc.identifier.urihttp://hdl.handle.net/2003/25635
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-8173
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 3, 2004en
dc.subjectCollagen a1(I) chainen
dc.subjectEhlers-Danlos syndromeen
dc.subjectprobabilityen
dc.subjectrandomnessen
dc.subjectvariantsen
dc.subject.ddc610
dc.titleSusceptible Amino Acid Pairs in Variants in Human Collagen alpha1(III) Chain Precursoren
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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