Induction of spinal long-term synaptic potentiation is sensitive to inhibition of neuronal NOS in L5 spinal nerve-transected rats
| dc.contributor.author | Bahari, Zahra | |
| dc.contributor.author | Manaheji, Homa | |
| dc.contributor.author | Hosseinmardi, Narges | |
| dc.contributor.author | Meftahi, Gholam Hossein | |
| dc.contributor.author | Sadeghi, Mehdi | |
| dc.contributor.author | Danialy, Samira | |
| dc.contributor.author | Noorbakhsh, Seyed Mohammad | |
| dc.date.accessioned | 2014-11-25T13:15:32Z | |
| dc.date.available | 2014-11-25T13:15:32Z | |
| dc.date.issued | 2014-07-14 | |
| dc.description.abstract | The role of neuronal nitric oxide synthase (nNOS) in the central mechanism of neuropathic pain and long-term potentiation (LTP) of peripheral afferents remains obscure. The current study investigated the effect of intrathecal application of 7-nitroindazole (7-NI), a selective nNOS inhibitor (8.15 μg/5μl), on mechanical allodynia on day 14 after L5 spinal nerve transection. Furthermore, using in vivo single unit extracellular recording, we examined the effect of 7-NI on the induction of LTP of Aδ- and C-fiber-evoked responses. We have demonstrated that 7-NI attenuates nerve-injury-evoked mechanical allodynia. Additionally, our electrophysiological study has shown that the spinal administration of 7-NI significantly inhibits the induction of the LTP of Aδ- and C-fiber-evoked responses on day 14 after neuropathy. These data suggest that activation of nNOS may be crucial for the induction of the spinal LTP of Aδ- and C-fiber-evoked responses following peripheral nerve damage. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/33708 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-6845 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 13, 2014 | en |
| dc.subject | neuropathic pain | en |
| dc.subject | nNOS | en |
| dc.subject | LTP | en |
| dc.subject | dorsal horn | en |
| dc.subject.ddc | 610 | |
| dc.title | Induction of spinal long-term synaptic potentiation is sensitive to inhibition of neuronal NOS in L5 spinal nerve-transected rats | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |