Genetical and statistical aspects of polymerase chain reactions

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Date

2000

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Publisher

Universitätsbibliothek Dortmund

Abstract

In this paper we describe the principles of polymerase chain reaction (PCR) and its expanding use in molecular genetic research and molecular medicine. A short introduction of exemplary applications of the PCR is connected with a discussion of the lack of PCR accuracy. We give a statistical model for the PCR and discuss estimation methods in order to quantify the lack of PCR accuracy.

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Keywords

branching process, estimation of the mutation rate., lack of PCR accuracy, polymerase chain reaction

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