Genetical and statistical aspects of polymerase chain reactions
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Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
Universitätsbibliothek Dortmund
Abstract
In this paper we describe the principles of polymerase chain reaction (PCR) and its expanding use in molecular genetic research and molecular medicine. A short introduction of exemplary applications of the PCR is connected with a discussion of the lack of PCR accuracy. We give a statistical model for the PCR and discuss estimation methods in order to quantify the lack of PCR accuracy.
Description
Table of contents
Keywords
branching process, estimation of the mutation rate., lack of PCR accuracy, polymerase chain reaction