Changes in Liver Function correlate with the Improvement of Lipid Profile after Restoration of Euthyroidism in Patients with Subclinical Hypothyroidism

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dc.contributor.authorChrist-Crain, Mirjamde
dc.contributor.authorHuber, Peter R.de
dc.contributor.authorKeller, Ulrichde
dc.contributor.authorMeier, Christiande
dc.contributor.authorMüller, Beatde
dc.contributor.authorPuder, Jardenade
dc.contributor.authorStaub, Jean-Jacquesde
dc.date.accessioned2008-06-17T13:45:32Z
dc.date.available2008-06-17T13:45:32Z
dc.date.issued2004-01-12de
dc.description.abstractOvert hypothyroidism frequently leads to liver dysfunction. Subclinical hypothyroidism (SCH) is linked to abnormalities of lipoprotein metabolism, however, data on liver function are lacking. We analyzed the effects of L-thyroxine (L-T4) therapy on liver function and their association with changes of serum lipoproteins in SCH as part of a prospective, double-blind study. 66 women with SCH were randomly assigned to receive either L-thyroxine or placebo for 48 weeks. Circulating liver and biliary enzymes as well as serum lipid levels were assessed at baseline and after 24 and 48 weeks. Alkaline phosphatase as parameter of hepato-biliary function increased after 48 weeks of L-T4 treatment (p=0.004). Circulating levels of alanine amino transferase (ALT) and serum aspartate transferase (AST) did not change during L-T4 treatment. However, there was a correlation between both, deltaAST and deltaALT with delta-total cholesterol (r=0.60, p<0.001 and r=0.52, p=0.002, respectively). Similarly, both, deltaAST and deltaALT, correlated with deltaLDL cholesterol (LDL-C), respectively. Consecutively, patients with marked decrease of serum lipids during L-T4 therapy had a significantly higher decrease in AST and ALT, respectively, as compared to patients without amelioration of the lipid profile. Thyroid hormone replacement in SCH affects biliary tract function, yet, has no overall effect on hepatocellular enzymes. The relatively strong correlation between changes of serum AST and ALT with changes of LDL-C levels suggests that the mechanism of decreased LDL-C observed in restoration of euthyroidism in patients with SCH might be caused in part by changes of hepatic lipoprotein catabolism and a restored hepato-cellular function.en
dc.description.sponsorshipSupported by grants from the Swiss National Science Foundation (32.27866.89, 32.37792.93, and 32.37792.98) and unconditional research grants from Henning Berlin, Novartis, Roche Research, Nora van Meeuwen-Häfliger, and Krokus Foundations and the "Sonderprogramm zur Förderung des akademischen Nachwuchses der Universität Basel" (to BM)en
dc.identifier.issn1611-2156de
dc.identifier.urihttp://hdl.handle.net/2003/25633
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-14916
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 3, 2004en
dc.subjecthypothyroidismen
dc.subjectliveren
dc.subjectthyroxineen
dc.subject.ddc610
dc.titleChanges in Liver Function correlate with the Improvement of Lipid Profile after Restoration of Euthyroidism in Patients with Subclinical Hypothyroidismen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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