Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats
| dc.contributor.author | Budin, Siti Balkis | |
| dc.contributor.author | Idris, Muhd Hanis Md | |
| dc.contributor.author | Mohamed, Jamaludin | |
| dc.contributor.author | Osman, Mohamad | |
| dc.date.accessioned | 2012-11-16T12:16:16Z | |
| dc.date.available | 2012-11-16T12:16:16Z | |
| dc.date.issued | 2012-11-16 | |
| dc.description.abstract | Diabetes mellitus contributes to male sexual dysfunction and infertility by modulating oxidative damage. To date, a number of studies have demonstrated antioxidant properties of Hibiscus sabdariffa Linn. This study was designed to investigate the effects of H. sabdariffa UKMR-2 variety on sperm functioning of streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were allotted into four groups, namely control group (C), H. sabdariffa extract (HSE) group, diabetes group (D) and diabetes plus HSE group (D+HSE). HSE (100 mg/kg/body weight) was administered orally for 28 consecutive days. After 28-days of supplementation, the rats were sacrificed to obtain epididymal sperm. Administration of HSE significantly lowered the level of fasting blood glucose and increased plasma insulin level in D+HSE group as compared to D group (p<0.05). Sperm quality in the D+HSE group was improved with significantly higher sperm concentrations (p<0.05) and sperm motility (p<0.001) as well as lower percentage of sperm abnormality (p<0.05) as compared to the diabetic group. Plasma follicle-stimulating hormone (FSH) level was significantly elevated (p<0.05) in D+HSE group than in D group while no significant alteration in plasma testosterone and luteinizing hormone (LH) level were seen between groups. In conclusion, this study suggested that H. sabdariffa UKMR-2 variety has a potential protective role against diabetes-induced sperm damage. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/29784 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-5145 | |
| dc.language.iso | en | de |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 11, 2012 | en |
| dc.subject | diabetes | en |
| dc.subject | Hibiscus sabdariffa UKMR-2 | en |
| dc.subject | oxidative stress | en |
| dc.subject | sperm damage | en |
| dc.subject.ddc | 610 | |
| dc.title | Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats | en |
| dc.type | Text | de |
| dc.type.publicationtype | article | de |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |