Evaluating the relationship of blood pressure, plasma angiotensin peptides and aldosterone with cognitive functions in patients with hypertension
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Date
2017-03-10
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Abstract
Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of
hypertension. On the other hand, hypertension is a well-known and independent risk factor for
cognitive impairment. The aim of the present study was to evaluate the relationship of blood
pressure control, plasma angiotensin peptides and aldoste- rone with cognitive functions. Forty-one
patients who were under treatment with the same antihypertensive med- ications for at least three
months were included in the study. Plasma angiotensin II, angiotensin 1-7, angiotensin IV, and
aldosterone concentrations were analyzed using an enzyme-linked immunosorbent assay (ELISA). Stand-
ardized Mini Mental State Examination (SMMSE) was used to evaluate cognitive functions. When the
participants were grouped according to their SMMSE scores (cut-off value: 26 points), we determined
significant differences between systolic blood pressure (SBP) levels, diastolic blood pressure
levels, plasma angiotensin II and angioten- sin 1-7 concentrations of the groups. When the
participants were stratified according to their SBP levels (cut-off value: 140 mm Hg), we found
significant differences in SMMSE scores and plasma angiotensin IV concentrations of the groups. A
negative correlation between SBP and SMMSE scores and strong linear correlations among an-
giotensin peptides levels were determined. The relationship found between SBP and SMMSE in the
present study was compatible with the literature. Our 33 patients were using at least one
angiotensin II receptor blocker (ARB). Regarding AT1 receptor blockage, the significant association
between higher SMMSE scores and increased angi- otensin peptides may support a finding that ARBs
prevent dementia and improve cognitive function. Further larger studies are needed to confirm and
prove the relation of RAAS biochemical parameters with cognitive function.
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Keywords
hypertension, cognitive functions, angiotensin, aldosterone