COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
| dc.contributor.author | Muhammad, Aminu | |
| dc.contributor.author | Sirat, Hasnah Mohd | |
| dc.date.accessioned | 2014-03-11T13:57:41Z | |
| dc.date.available | 2014-03-11T13:57:41Z | |
| dc.date.issued | 2013-09-13 | |
| dc.description.abstract | Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 μM). | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/32961 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7476 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 12, 2013 | en |
| dc.subject | COX-2 | de |
| dc.subject | Bauhinia rufescens | en |
| dc.subject | phytochemicals | en |
| dc.subject.ddc | 610 | |
| dc.title | COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae) | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |