COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)

dc.contributor.author	Muhammad, Aminu
dc.contributor.author	Sirat, Hasnah Mohd
dc.date.accessioned	2014-03-11T13:57:41Z
dc.date.available	2014-03-11T13:57:41Z
dc.date.issued	2013-09-13
dc.description.abstract	Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 μM).	en
dc.identifier.issn	1611-2156
dc.identifier.uri	http://hdl.handle.net/2003/32961
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-7476
dc.language.iso	en
dc.relation.ispartofseries	EXCLI Journal ; Vol. 12, 2013	en
dc.subject	COX-2	de
dc.subject	Bauhinia rufescens	en
dc.subject	phytochemicals	en
dc.subject.ddc	610
dc.title	COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)	en
dc.type	Text
dc.type.publicationtype	article
dcterms.accessRights	open access
eldorado.dnb.deposit	true	de
eldorado.dnb.zdberstkatid	2132560-1

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