Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies

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dc.contributor.authorAladag, Mustafa Onur
dc.contributor.authorKoƧ, Ziya Erdem
dc.contributor.authorUysal, Ahmet
dc.date.accessioned2013-08-15T12:26:38Z
dc.date.available2013-08-15T12:26:38Z
dc.date.issued2013-08-15
dc.description.abstractTwo monopodal (2,4-dichloro-6-(3-hydroxytyramine)-1,3,5-triazine) and tripodal (2,4,6-(3-hydroxytyramine)-1,3,5-triazine) s-triazine derivatives were prepared through the reaction of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and 3-hydroxytyramine hydrochloride (do-pamine hydrochloride). The structures of the compounds were identified by FT-IR, 1H NMR, 13C NMR, thermal analysis and elemental analysis. Their antimicrobial activities were car-ried out using the broth microdilution method in dimethyl sulfoxide (DMSO): Phosphate Buffered Saline (PBS) against eight bacteria and one yeast. The results of the test were com-pared with ampicillin. It was determined that CCDOP1, CCDOP3 and DOP have significant antibacterial and antifungal activity. These three chemicals revealed strong antibacterial activ-ity against the E. coli and S. aureus strains used in the study. S. aureus was the most sensitive strain against dopamine hydrochloride and E. coli was the most sensitive bacteria against CCDOP1.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/30488
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-10849
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectantimicrobial activityen
dc.subjectbroth microdilutionen
dc.subjectcyanuric chloride,en
dc.subjectdopamineen
dc.subject.ddc610
dc.titleSynthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studiesen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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