Hepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) against carbon tetrachloride induced liver injury in rats

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dc.contributor.authorIkewuchi, Catherine C.
dc.contributor.authorIkewuchi, Jude C.
dc.contributor.authorOnyeike, Eugene N.
dc.contributor.authorUwakwe, Augustine A.
dc.date.accessioned2012-09-20T12:29:53Z
dc.date.available2012-09-20T12:29:53Z
dc.date.issued2012-09-20
dc.description.abstractThe potential of aqueous extract of the leaves of Acalypha wilkesiana, to protect against carbon tetrachloride induced liver damage was investigated in Wistar albino rats. The carbon tetrachloride was prepared 1:5 (v:v) in olive oil, and administered subcutaneously at 1 mL/kg body weight. The extract was administered to both normal and carbon tetrachloride treated rats at 100, 200 and 300 mg/kg. On fractionation and gas chromatographic analysis of the crude aqueous extract, thirty nine known alkaloids were detected, consisting mainly of akuamidine (69.027 %), voacangine (26.226 %), echitamine (1.974 %), echitamidine (0.599 %), lupanine (0.521 %) and augustamine (0.278 %). Compared to test control, the treatment dose dependently produced significantly lower (P<0.05) alkaline phosphatase, aspartate and alanine transaminase activities. Histopathological studies on the liver sections showed that pre-treatment with the extract protected against carbon tetrachloride induced fatty degeneration of hepatocytes, thus, confirming the results of the biochemical studies. The above results imply that treatment with the plant extract protects the liver against carbon tetrachloride induced hepatotoxicity, therefore, justifying the use of Acalypha wilkesiana in African traditional health care for the management of liver problems.en
dc.identifier.urihttp://hdl.handle.net/2003/29631
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-14395
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 10, 2011en
dc.subjectAcalypha wilkesiana ‘Godseffiana’ Muell Arg (Euphorbiaceae)en
dc.subjectcarbon tetrachlorideen
dc.subjecthepatospecific markersen
dc.subjecthistopathologyen
dc.subject.ddc610
dc.titleHepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) against carbon tetrachloride induced liver injury in ratsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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