Investigation on biological activities of anthranilic acid sulfonamide analogs

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dc.contributor.authorDoungsoongnuen, Sutanun
dc.contributor.authorPingaew, Ratchanok
dc.contributor.authorPrachayasittikul, Supaluk
dc.contributor.authorPrachayasittikul, Virapong
dc.contributor.authorRuchirawat, Somsak
dc.contributor.authorSuksrichavalit, Thummaruk
dc.contributor.authorWorachartcheewan, Apilak
dc.date.accessioned2011-12-02T09:45:01Z
dc.date.available2011-12-02T09:45:01Z
dc.date.issued2011-12-02
dc.description.abstractIn the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50 % inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.en
dc.identifier.urihttp://hdl.handle.net/2003/29203
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-3249
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 10, 2011en
dc.subjectanthranilic aciden
dc.subjectantimicrobialsen
dc.subjectantioxidantsen
dc.subjectcytotoxicityen
dc.subjectsulfonamidesen
dc.subject.ddc610
dc.titleInvestigation on biological activities of anthranilic acid sulfonamide analogsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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