Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas

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dc.contributor.authorSajed, Roya
dc.contributor.authorSaeednejad Zanjani, Leili
dc.contributor.authorRahimi, Mandana
dc.contributor.authorMansoori, Maryam
dc.contributor.authorZarnani, Amir-Hassan
dc.contributor.authorMadjd, Zahra
dc.contributor.authorGhods, Roya
dc.date.accessioned2020-12-15T12:56:02Z
dc.date.available2020-12-15T12:56:02Z
dc.date.issued2020-10-29
dc.description.abstractDynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the development of several cancers such as prostate, pancreas, and bladder. However, its clinical significance in breast cancer is unclear yet. In the present study, the membranous, cytoplasmic, and nuclear expression levels of dynamin 2 molecule were evaluated for the first time, using immunohistochemistry (IHC) on tissue microarray (TMA) slides in 113 invasive breast cancer tissues. Moreover, afterward, the association between the dynamin 2 expression and clinicopathological features was determined. Our finding showed that, a higher nuclear expression of dynamin 2 is significantly associated with an increase in tumor stage (P = 0.05), histological grade (P = 0.001), and age of the patients (P = 0.03). In addition, analysis of the cytoplasmic expression levels of this molecule revealed that, there was a statistically significant difference between the expression levels of dynamin 2 among the different breast cancer subtypes (P = 0.003). Moreover, a significant association was found between the increased expression of dynamin 2 membranous and vascular invasion (VI) (P = 0.02). We showed that dynamin 2 protein expression has an association with more aggressive tumor behavior and more advanced disease in the patients with breast cancer; therefore, dynamin 2 molecule could be considered as an indicator of disease progression and aggressiveness.en
dc.identifier.citationSajed, R., Saeednejad Zanjani, L., Rahimi, M. ., Mansoori, M. ., Zarnani, A.-H. ., Madjd, Z. ., & Ghods, R. (2020). Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas. EXCLI Journal, 19, 1423-1435. https://doi.org/10.17179/excli2020-2762en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39900
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21790
dc.language.isoen
dc.publisherIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmunden
dc.relation.ispartofseriesEXCLI Journal;Vol. 19 2020
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDynamin 2en
dc.subjectBreast canceren
dc.subjectImmunohistochemistryen
dc.subjectTissue microarray (TMA)en
dc.subjectInvasionen
dc.subjectCancer progressionen
dc.subject.ddc610
dc.titleOverexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomasen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.identifier.urlhttps://www.excli.de/index.php/excli/article/view/2762
eldorado.secondarypublicationtrue

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