PH-sensitive, polymer modified, plasma stable niosomes: promising carriers for anti-cancer drugs
| dc.contributor.author | Tila, Dena | |
| dc.contributor.author | Yazdani - Arazi, Seyede Narjes | |
| dc.contributor.author | Ghanbarzadeh, Saeed | |
| dc.contributor.author | Arami, Sanam | |
| dc.contributor.author | Pourmoazzen, Zhaleh | |
| dc.date.accessioned | 2015-04-21T07:07:54Z | |
| dc.date.available | 2015-04-21T07:07:54Z | |
| dc.date.issued | 2015-01-06 | |
| dc.description.abstract | The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymer introduced simultaneously pH-sensitivity and plasma stability properties in prepared niosomes. The pH-sensitivity and cytotoxicity of Mitoxantrone niosomes were evaluated in vitro in phosphate buffer with different pHs as well as using human ovarian cancer cell line (OVCAR-3), human breast cancer cell line (MCF-7) and human umbilical vein endothelial cells (HUVEC). Results showed that both cholesterol derivatives bearing formulations had pH-sensitive property and were found to release their contents under mild acidic conditions rapidly. In addition, the PEG-PMMI-CholC6-based niosomes could reserve the pH-sensitivity after incubation in plasma. Both Mitoxantrone-loaded pH-sensitive niosomes showed higher cytotoxicity than the conventional niosomes on OVCAR-3 and MCF-7 cell lines. However, both pH-sensitive niosomes exhibited lower cytotoxic effect on HUVEC cell line. Plasma stable, pH-sensitive niosomes could improve the cytotoxic effect and reduce the side effects of anti-tumor drugs. | en |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/34011 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7465 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal ; Vol. 14, 2015 | en |
| dc.subject | pH-sensitive plasma stable niosome | en |
| dc.subject | cytotoxic effect | en |
| dc.subject | Mitoxantrone | en |
| dc.subject.ddc | 610 | |
| dc.title | PH-sensitive, polymer modified, plasma stable niosomes: promising carriers for anti-cancer drugs | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |