Anti-inflammatory activity of hydrosols from Tetragonia tetragonoides in LPS-induced RAW 264.7 cells

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dc.contributor.authorKo, Eun-Yi
dc.contributor.authorCho, Su-Hyeon
dc.contributor.authorKang, Kyungpil
dc.contributor.authorKim, Gibeom
dc.contributor.authorLee, Ji-Hyeok
dc.contributor.authorJeon, You-Jin
dc.contributor.authorKim, Daekyung
dc.contributor.authorAhn, Ginnae
dc.contributor.authorKim, Kil-Nam
dc.date.accessioned2017-10-25T13:37:18Z
dc.date.available2017-10-25T13:37:18Z
dc.date.issued2017-04-18
dc.description.abstractThe present study was performed to investigate the anti-inflammatory activity of Tetragonia tetragonoides hydro- sols (TTH) and its underlying mechanism in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Gas chromatog- raphy (GC) coupled with mass spectrometry and retention index calculations showed that TTH were mainly com- posed of tetratetracontane (29.5 %), nonacosane (27.6 %), and oleamide (17.1 %). TTH significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, and IL-1β in LPS-stimulated RAW 264.7 cells. Consistent with these observations, TTH treatment decreased the protein expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). The molecular mechanism of its anti-inflamma- tory activity was found to be associated with inhibition of nuclear factor-kappa B (NF-κB) phosphorylation and nuclear translocation of NF-κB 65. Furthermore, TTH markedly suppressed the LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs). Taken together, these data indicate that TTH exerts an anti-inflam- matory activity by inhibiting the NF-κB and MAPK signaling pathways in LPS-stimulated RAW 264.7 cells.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36140
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18156
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTetragonia tetragonoidesen
dc.subjecthydrosolsen
dc.subjectanti-inflammatoryen
dc.subjectNF- κBen
dc.subjectMAPKsen
dc.subject.ddc610
dc.titleAnti-inflammatory activity of hydrosols from Tetragonia tetragonoides in LPS-induced RAW 264.7 cellsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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