Therapeutic effect of Baccharis anomala DC. extracts on activated hepatic stellate cells

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dc.contributor.authorSouza Basso, Bruno de
dc.contributor.authorMesquita, Fernanda Cristina de
dc.contributor.authorBregolin Dias, Henrique
dc.contributor.authorKrause, Gabriele Catyana
dc.contributor.authorScherer, Matheus
dc.contributor.authorRomanato Santarém, Eliane
dc.contributor.authorRodrigues de Oliveira, Jarbas
dc.date.accessioned2019-05-22T14:29:07Z
dc.date.available2019-05-22T14:29:07Z
dc.date.issued2019-02-18
dc.description.abstractThe therapeutic potential of Baccharis anomala DC. extracts was evaluated through its cytotoxic and antiproliferative effect and their phenotypic reversion property in activated hepatic stellate cells (HSCs). Baccharis anomala is distributed in Brazil (southeastern and south regions) and used for diuretic effect in folk medicine. Four fractions were obtained from the fractionation of the methanolic extract. Fractions III and IV decreased cell proliferation without increasing cell necrosis markers levels and induced cell cycle arrest in G1 phase. Fraction III induced phenotypic reversion through PPAR-γ activation pathway, while fraction IV did not alter PPAR-α/γ expression levels, suggesting that there is an independent PPAR-α/γ pathway involved. Hydroxybenzoic, chlorogenic and coumaric acids were identified. Fractions III and IV showed antiproliferative effect and ability to induce reversion of activated phenotype of HSCs.de
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/38068
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20050
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 18 2019
dc.subjectHepatic fibrosisde
dc.subjectHSCsde
dc.subjectBaccharisde
dc.subjectPPAR-γde
dc.subjectPhenolic compoundsde
dc.subject.ddc610
dc.titleTherapeutic effect of Baccharis anomala DC. extracts on activated hepatic stellate cellsde
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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