Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells

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dc.contributor.authorKang, Min-Cheol
dc.contributor.authorHam, Young-Min
dc.contributor.authorHeo, Soo-Jin
dc.contributor.authorYoon, Seon-A
dc.contributor.authorCho, Su-Hyeon
dc.contributor.authorKwon, Seung-Hae
dc.contributor.authorJeong, Myeong Seon
dc.contributor.authorJeon, You-Jin
dc.contributor.authorSanjeewa, KKA
dc.contributor.authorYoon, Weon-Jong
dc.contributor.authorKim, Kil-Nam
dc.date.accessioned2018-11-12T14:45:08Z
dc.date.available2018-11-12T14:45:08Z
dc.date.issued2018-08-02
dc.description.abstractThe aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. With respect to proinflammatory signaling pathways, OOA inhibited LPS-induced mitogen-activated protein kinase signaling by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Moreover, OOA inhibited LPS-induced nuclear factor (NF)-κB signaling by reducing the phosphorylation of IκB-α and p50 proteins. These results indicate that OOA significantly reduces proinflammatory signaling, which results in reduced expression of cytokines and proinflammatory mediators. Taken together, these results suggest that OOA has potent anti-inflammatory effects and could be considered an effective anti-inflammatory agent.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37662
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19657
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.subject8-Oxo-9-octadecenoic aciden
dc.subjectAnti-inflammatoryen
dc.subjectUndaria petersenianaen
dc.subjectMacrophagesen
dc.subjectLipopolysaccharideen
dc.subject.ddc610
dc.titleAnti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cellsen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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