Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae

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dc.contributor.authorKo, Eun-Yi
dc.contributor.authorYoon, Weon-Jong
dc.contributor.authorLee, Hae-Won
dc.contributor.authorHeo, Soo-Jin
dc.contributor.authorKo, Young-Hwan
dc.contributor.authorFernando, I.P. Shanura
dc.contributor.authorCho, Kichul
dc.contributor.authorLee, Chi-Heon
dc.contributor.authorHur, Sung-Pyo
dc.contributor.authorCho, Su-Hyeon
dc.contributor.authorAhn, Ginnae
dc.contributor.authorKim, Daekyung
dc.contributor.authorKim, Kil-Nam
dc.date.accessioned2016-11-24T15:05:59Z
dc.date.available2016-11-24T15:05:59Z
dc.date.issued2016-06-28
dc.description.abstractThe anti-inflammatory properties of the supercritical fluid extract of Ishige okamurae (SFEIO) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. The lipid profile of the SFEIO, reviled the presence of palmitic acid (220.2 mg/g), linoleic acid (168.0 mg/g), and oleic acid (123.0 mg/g). SFEIO was found to exert it’s anti-inflammatory effects through inhibiting nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 production in LPS-stimulated RAW 264.7 cells, without inducing cytotoxicity. SFEIO did not effect on the LPS-induced p38 kinase phosphorylation, whereas it attenuated the extracellular-related signaling kinase (ERK) and c-Jun N-terminal kinase (JNK) phosphorylation. Furthermore, SFEIO inhibited the LPS-induced IκB-α degradation and p50 NF-κB activation. These results suggest that SFEIO exerts its anti-inflammatory effects in LPS-activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-κB.en
dc.identifier.doi10.17179/excli2016-337
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35618
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17659
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 15, 2016en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectsupercritical fluid extractionen
dc.subjectlinoleic aciden
dc.subjectIshige okamuraeen
dc.subjectanti-inflammatoryen
dc.subjectNF- κBen
dc.subject.ddc610
dc.titleAnti-inflammatory effect of supercritical extract and its constituents from Ishige okamuraeen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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