Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

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dc.contributor.authorAbd Rashid, Norhashima
dc.contributor.authorHussan, Farida
dc.contributor.authorHamid, Asmah
dc.contributor.authorAdib Ridzuan, Nurul Raudzah
dc.contributor.authorHalim, Syarifah Aisyah Syed Abdul
dc.contributor.authorAbdul Jalil, Nahdia Afiifah
dc.contributor.authorNajib, Nor Haliza Mohamad
dc.contributor.authorTeoh, Seong Lin
dc.contributor.authorBudin, Siti Balkis
dc.date.accessioned2020-12-14T14:46:36Z
dc.date.available2020-12-14T14:46:36Z
dc.date.issued2020-09-09
dc.description.abstractOxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and all animals were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1 and indicators of oxidative stress including malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status (glutathione, glutathione peroxidase, superoxide dismutase and catalase) as compared to cisplatin group. PmEO100CP pretreatment also modulated changes in liver inflammatory markers (TNF-α, IL-1α, IL-1β, IL-6 and IL-10). PmEO100CP administration also notably reduced cisplatin-induced apoptosis significantly as compared to cisplatin group. In conclusion, our results suggested that P. minus essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis.en
dc.identifier.citationAbd Rashid, N., Hussan, F., Hamid, A., Adib Ridzuan, N. R., Halim, S. A. S. A., Abdul Jalil, N. A., Najib, N. H. M., Teoh, S. L., & Budin, S. B. (2020). Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways. EXCLI Journal, 19, 1246-1265. https://doi.org/10.17179/excli2020-2355en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/39890
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-21780
dc.language.isoen
dc.publisherIfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmundde
dc.relation.ispartofseriesEXCLI Journal;Vol. 19. 2020, pp.1246-1265
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectApoptosisen
dc.subjectCisplatinen
dc.subjectHepatotoxicityen
dc.subjectInflammationen
dc.subjectPolygonum minus essential oilen
dc.subjectOxidative stressen
dc.subject.ddc610
dc.titlePolygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathwaysen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.identifier.urlhttps://doi.org/10.17179/excli2020-2355
eldorado.secondarypublicationtrue

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