Connexins and pannexins in liver damage
Loading...
Date
Authors
Crespo Yanguas, Sara
Willebrords, Joost
Maes, Michaël
da Silva, Tereza Cristina
Veloso Alves Pereira, Isabel
Cogliati, Bruno
Zaidan Dagli, Maria Lucia
Vinken, Mathieu
Journal Title
Journal ISSN
Volume Title
Publisher
Alternative Title(s)
Abstract
Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.
Description
Table of contents
Keywords
connexin, pannexin, acute liver injury, steatosis, hepatitis, cholestasis, fibrosis, liver cancer