Co-sorption of volatile components in polymer-based pharmaceutical formulations
| dc.contributor.author | Kerkhoff, Jana | |
| dc.contributor.author | Borrmann, Dominik | |
| dc.contributor.author | Sadowski, Gabriele | |
| dc.date.accessioned | 2026-01-08T08:11:16Z | |
| dc.date.available | 2026-01-08T08:11:16Z | |
| dc.date.issued | 2024-10-05 | |
| dc.description.abstract | Amorphous Solid Dispersions (ASDs) are mixtures of active pharmaceutical ingredients (APIs) and polymers aiming to increase API aqueous solubility and bioavailability. ASDs are often produced using solvent-based manufacturing, such as spray drying. Due to solubility or miscibility limitations in one solvent, solvent mixtures are frequently used for this purpose. Drying solvents or solvent mixtures from polymer-based products like ASDs is an energy-intensive and time-consuming process. Designing and optimising this drying process requires knowledge of the sorption isotherms of the solvent(s) in these polymer-based products. In this work, we developed a novel approach for measuring the simultaneous absorption/desorption of two solvents in a polymer. Combining classical dynamic vapour sorption (DVS) measurements with Raman spectroscopy, this innovative approach provides a more detailed and accurate measurement of the sorption isotherms than common methods. Moreover, we developed an approach for precisely predicting the sorption equilibria in three-component systems just based on sorption data of the corresponding binary subsystems. Our modelling approach combines the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) with the Non-Equilibrium Thermodynamics of Glassy Polymers (NET-GP). Building on the description of the sorption isotherms of either water or ethanol in poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64) and in indomethacin (IND), we were able to quantitatively predict the simultaneous sorption of water and ethanol in PVPVA64 and the one of ethanol in an IND/PVPVA64 ASD. | en |
| dc.identifier.uri | http://hdl.handle.net/2003/44651 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | Fluid phase equilibria; 589 | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Co-sorption | en |
| dc.subject | Sorption isotherm | en |
| dc.subject | ASDs | en |
| dc.subject | Raman | |
| dc.subject | DVS | en |
| dc.subject | PC-SAFT | en |
| dc.subject | NET-GP | en |
| dc.subject.ddc | 660 | |
| dc.title | Co-sorption of volatile components in polymer-based pharmaceutical formulations | en |
| dc.type | Text | |
| dc.type.publicationtype | Article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.deposit | true | |
| eldorado.doi.register | false | |
| eldorado.secondarypublication | true | |
| eldorado.secondarypublication.primarycitation | Jana Kerkhoff, Dominik Borrmann, Gabriele Sadowski, Co-sorption of volatile components in polymer-based pharmaceutical formulations, Fluid Phase Equilibria, Volume 589, 2025, 114247, https://doi.org/10.1016/j.fluid.2024.114247 | |
| eldorado.secondarypublication.primaryidentifier | https://doi.org/10.1016/j.fluid.2024.114247 |