Extract of Ulmus davidiana Planch barks induced apoptosis in human hepatoma cell line HepG2

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dc.contributor.authorGuo, Jia
dc.contributor.authorWang, Myeong-Hyeon
dc.date.accessioned2009-07-08T07:27:52Z
dc.date.available2009-07-08T07:27:52Z
dc.date.issued2009-07-08T07:27:52Z
dc.description.abstractThe cytotoxicity and mechanism of cell death induced by an extract of Ulmus davidiana Planch (UDP) were investigated. A 70 % ethanol extract of UDP exerted cytotoxic effects on HepG2 cells in a time- and dose-dependent manner caused a significant dose-dependent increase in the number of apoptotic cells. In addition, obvious shrinkage and destruction of the monolayer were observed in UDP-treated cells, but not in untreated cells. RT-PCR analysis revealed that the mRNA expression of p53 and c-myc was markedly increased in cells treated with the plant extract. In contrast, caspase-3 expression was induced after 1 h of incubation and then decreased at 3 h; however, it subsequently increased and remained at a relatively high level thereafter. Our data suggest the presence of a bioactive compound capable of killing liver carcinoma cells by apoptosis in a 70 % ethanol extract of UDP, and that the mechanism of apoptosis in the HepG2 cells included p53 and c-myc signaling.en
dc.identifier.urihttp://hdl.handle.net/2003/26221
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7314
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 8, 2009en
dc.subject70 % ethanol extracten
dc.subjectapoptosisen
dc.subjectHepG2en
dc.subjectUlmus davidiana Planchen
dc.subject.ddc610
dc.titleExtract of Ulmus davidiana Planch barks induced apoptosis in human hepatoma cell line HepG2en
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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