High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome
| dc.contributor.author | Xu, Lihua | |
| dc.contributor.author | Guo, Yang | |
| dc.contributor.author | Yan, Wenying | |
| dc.contributor.author | Cen, Jiannong | |
| dc.contributor.author | Niu, Yuna | |
| dc.contributor.author | Yan, Qing | |
| dc.contributor.author | He, Hailong | |
| dc.contributor.author | Chen, Chien-Shing | |
| dc.contributor.author | Hu, Shaoyan | |
| dc.date.accessioned | 2017-08-25T08:46:44Z | |
| dc.date.available | 2017-08-25T08:46:44Z | |
| dc.date.issued | 2017-03-07 | |
| dc.description.abstract | Differential expression of microRNAs (miRNAs) has been implicated in leukemogenesis. We investigate the ex- pression pattern of miR-196b. Using quantitative real-time PCR (qRT-PCR), we detected the expression of miR- 196b and its correlated genes (SMC1A/MLH1) in initial pediatric AML. A significant association was observed between overexpression of miR-196b and inferior overall survival of pediatric AML (Log Rank P<0.0001). AML M4/5 subtype, high white blood cell (WBC) count at presentation, MLL rearrangement, or FLT3-ITD mutation at diagnosis and non-remission group after the first induction chemotherapy possessed higher miR-196b expression. Furthermore, a positive relationship was found between the expression of miR-196b and SMC1A/MLH1 (Spear- man’s r=0.37 and 0.44, P=0.001 and <0.0001, respectively). Taken together, these findings suggest that differen- tially high expression of miR-196b in diagnostic marrow samples of pediatric AML is associated with unfavorable outcome, and miR-196b potentially can be a novel biomarker for the diagnosis, prognosis and treatment in pediatric AML. | en |
| dc.identifier.doi | 10.17179/excli2016-707 | |
| dc.identifier.doi | 10.17179/excli2016-707 | |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/36065 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-18081 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 16 2017 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | miR-196b | en |
| dc.subject | AML | en |
| dc.subject | pediatric/child | en |
| dc.subject | biomarker | en |
| dc.subject.ddc | 610 | |
| dc.title | High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |