The effect of BLA GABAA receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA
| dc.contributor.author | Kangarlu-Haghighi, Katayoon | |
| dc.contributor.author | Oryan, Shahrbanoo | |
| dc.contributor.author | Nasehi, Mohammad | |
| dc.contributor.author | Zarrindast, Mohammad-Reza | |
| dc.date.accessioned | 2016-05-23T08:54:56Z | |
| dc.date.available | 2016-05-23T08:54:56Z | |
| dc.date.issued | 2015-05-11 | |
| dc.description.abstract | The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABAA receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABAA receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABAA receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA. | en |
| dc.identifier.doi | 10.17179/excli2015-201 | |
| dc.identifier.issn | 1611-2156 | |
| dc.identifier.uri | http://hdl.handle.net/2003/35003 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-17051 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | EXCLI Journal;Vol. 14, 2015 | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | ACPA | en |
| dc.subject | GABA | en |
| dc.subject | anxiety | en |
| dc.subject | memory | en |
| dc.subject | amygdala | en |
| dc.subject.ddc | 610 | |
| dc.title | The effect of BLA GABAA receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA | en |
| dc.type | Text | |
| dc.type.publicationtype | article | |
| dcterms.accessRights | open access | |
| eldorado.dnb.zdberstkatid | 2132560-1 |