Colorectal cancer in Iran
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Date
2016-11-28
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Abstract
Colorectal cancer is one of the most prevalent cancers in different countries, including Iran. No
comprehensive study has been done in the country for colorectal cancer, but information on the
incidence and trends is essential to planning. This study aimed to evaluate the occurrence and
morphology of colorectal cancer and its trend in Iran. This study was conducted using data from the
national cancer registry system in Iran from 2003-2008. We used joinpoint regression analysis for
assessing incidence time trends and morphology change percentage. Of all cases of colorectal
cancer, 61.83 % were colon cancer, 27.54 % rectal cancer, 7.46 % rectosigmoid cancer, and
3.10 anal cancer. The most common histological types with the frequencies of 80.85 % was related to
adenocar- cinoma, NOS. The Annual percentage changes (APC) in ASIR for colorectal cancer
significantly increased in both men and women. APC in ASIR was 13.7 (CI: 10.5-17.1) in women and
16.4 (CI: 12.4-20.5) in men. APC of adenocarcinoma in villous adenoma showed significant declining
trend (p<0.05), while APC of adenocarci- noma, NOS had a constant trend. The incidence of the
cancer in recent years has increased in Iran because of changes in lifestyle and diet. Therefore,
further studies are necessary to detect the cause of this cancer and per- form preventive measures.
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Keywords
colorectal cancer, epidemiology, morphology, trend, Iran