Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats

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dc.contributor.authorAbdel Salam, Omar M. E.
dc.contributor.authorShaffie, Nermeen M.
dc.contributor.authorSleem, Amany A.
dc.date.accessioned2009-03-11T10:24:25Z
dc.date.available2009-03-11T10:24:25Z
dc.date.issued2009-03-11T10:24:25Z
dc.description.abstractThe aim of this study was to investigate the effect of citric acid or the sweetening agent aspartame on the CCl4-induced hepatic injury in rats. Citric acid (10 mg/kg, 100 mg/kg or 1000 mg/kg), aspartame (0.625 or 1.25 mg/kg) or silymarin (25 mg/kg) was given once daily orally simultaneously with CCl4 and for one week thereafter. The administration of citric acid at 100 mg/kg or 1000 mg/kg to CCl4-treated rats reduced elevated plasma ALT by 44.1-63.3 %, AST by 47.8-70.6 %, ALP by 41.7-67.2 %, respectively compared to controls. Aspartame at 0.625 or 1.25 mg/kg reduced plasma ALT by 39.8-52.0 %, AST by 43.2-52.4 % and ALP by 50.0-68.5 %, respectively. Meanwhile, silymarin at 25 mg/kg reduced ALT, AST and ALP levels by 52.7, 62.2 and 64.7 %, respectively. On histology, citric acid at 1000 mg/kg resulted in near normalization of liver tissue. Vacuolar degeneration and necrosis were markedly reduced by 1.25 mg/kg aspartame. These results indicate that treatment with citric acid or the sweetening agent aspartame protects against hepatocellular necrosis induced by CCl4.en
dc.identifier.urihttp://hdl.handle.net/2003/26039
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-15693
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal ; Vol. 8, 2009en
dc.subjectacute hepatic injuryen
dc.subjectaspartameen
dc.subjectcarbon tetrachlorideen
dc.subjectcitric aciden
dc.subjectraten
dc.subjectsilymarinen
dc.subject.ddc610
dc.titleHepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in ratsen
dc.typeText
dc.type.publicationtypearticleen
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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