Nephroprotective action of Peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

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dc.contributor.authorAhmad, Shiekh Tanveer
dc.contributor.authorAsiaf, Asia
dc.contributor.authorAslam, Mohammad
dc.contributor.authorBhat, Jalal Uddin
dc.contributor.authorDayal, Rameshver
dc.contributor.authorJavid, Kalim
dc.contributor.authorNafees, Sana
dc.contributor.authorSamim, Mohammad
dc.contributor.authorSingh, Surender
dc.contributor.authorUmar, Sadiq
dc.contributor.authorWani, Arjumand
dc.date.accessioned2012-11-15T15:10:34Z
dc.date.available2012-11-15T15:10:34Z
dc.date.issued2012-11-15
dc.description.abstractCadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pretreatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl2 administration.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/29761
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-5138
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 11, 2012en
dc.subjectcadmium chlorideen
dc.subjectnephrotoxicityen
dc.subjectPeucedanum grandeen
dc.subjectROSen
dc.subject.ddc610
dc.titleNephroprotective action of Peucedanum grande against cadmium chloride induced renal toxicity in Wistar ratsen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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