Seromolecular assess of Toxoplasma gondii infection in pregnant women and neonatal umbilical cord blood
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Date
2019-01-02
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Abstract
Toxoplasmosis is considered as one of the most prevalent human parasitic infections that can be transmitted from
mother to the fetus. The onset of toxoplasmosis during pregnancy has clinical complications including spontaneous
abortion, preterm labor, stillbirth and fetal abnormalities. The aim of this study was to investigate the prevalence
of Toxoplasmosis infection in pregnant women and their infants in Lorestan province, Western Iran. Blood and
sera samples were collected from 98 pregnant women and their infants. All collected samples were examined for
Toxoplasma gondii infection by serological tests (ELISA IgM & IgG) and PCR assay. Among the 98 samples of
mother and umbilical cord prevalence of anti-Toxoplasma IgG, was 34/98 (34.69 %) and 33/98 (33.67 %), respectively.
All pregnant women were negative for, anti-Toxoplasma IgM while it was found in 5/98 (5.1 %) of umbilical
cords. Based on PCR analysis, Toxoplasma infection was detected in 5 (5.1 %) and 7 (7.14 %) of mother and
umbilical cords, respectively. Molecular test along with evaluation of IgM (P <0.001) and IgG (P = 0.001) were
significantly correlated.
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Keywords
Pregnant women, Cord blood, Serological methods, Molecular methods