Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae

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dc.contributor.authorLawung, Ratana
dc.contributor.authorCherdtrakulkiat, Rungrot
dc.contributor.authorNabu, Sunanta
dc.contributor.authorPrachayasittikul, Supaluk
dc.contributor.authorIsarankura-Na-Ayudhya, Chartchalerm
dc.contributor.authorPrachayasittikul, Virapong
dc.date.accessioned2019-02-01T12:05:16Z
dc.date.available2019-02-01T12:05:16Z
dc.date.issued2018-08-23
dc.description.abstractThe multidrug resistance of Neisseria gonorrhoeae becomes a public health problem worldwide, especially the strain H041 that showed the decrease susceptibility to ceftriaxone which is the last resort for gonorrhea treat- ment. Therefore, the simultaneous discovery and development of a new compound to fight this pathogen is ur- gently required. In this study, 8-hydroxyquinoline (8HQ) and derivatives were evaluated for their antimicrobial activities against the gonococcal pathogen using spectinomycin as the reference drug. The results showed that 8HQ derivatives gave an excellent antimicrobial potency. Particularly, the dihalogenated 8HQ (iodoquinol, clio- quinol and 5,7-diCl-8HQ) exerted the high activity with MIC range of 0.08-0.15 µM, 0.10-0.20 µM and 0.28- 0.56 µM, respectively, compared with the reference drug (MIC = 16 µg/mL or 48.14 µM). Moreover, these compounds were also shown to be non-cytotoxic/very high safety index. The findings reveal that these three compounds could be further developed as a new antimicrobial agent for fighting the gonorrheal disease.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/37896
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-19883
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 17 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNeisseria gonorrhoeaeen
dc.subjectAntimicrobial resistanceen
dc.subjectAntibacterial activityen
dc.subject8-hydroxyquinoline and derivativesen
dc.subject.ddc610
dc.titleRepositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeaeen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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