The relationship between serum levels of fibroblast growth factor 21 and diabetic retinopathy

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dc.contributor.authorMousavi, Zohre
dc.contributor.authorBonakdaran, Shokoufeh
dc.contributor.authorSahebkar, Amirhossein
dc.contributor.authorYaghoubi, Gholamhossein
dc.contributor.authorYaghoubi, Mohammad Ali
dc.contributor.authorDavoudian, Najmeh
dc.contributor.authorMohebbi, Masoud
dc.date.accessioned2018-02-05T13:08:04Z
dc.date.available2018-02-05T13:08:04Z
dc.date.issued2017-11-22
dc.description.abstractFibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done. Since the association between FGF21 and diabetic retinopathy is not clear, this study was conducted to investi- gate this relationship. In this cross-sectional study, 61 subjects (14 healthy controls, 22 diabetic patients without retinopathy, and 25 patients with diabetic retinopathy) were evaluated. All patients in the study were examined for the presence of diabetic retinopathy. Various clinical and biochemical parameters including FGF21 were evaluated and analyzed and compared between the study groups. Serum levels of FGF21 showed a significant difference between the three groups (P=0.003) but the difference between diabetic patients with and without ret- inopathy was not significant (P=0.122). Regression model was used to evaluate the role of FGF21 in predicting diabetic retinopathy. In the multivariate logistic regression model after adjustment of systolic blood pressure and fasting blood glucose, the level of FGF21 was not associated with diabetic retinopathy. In the multivariate mod- el, only fasting blood glucose was associated with diabetic retinopathy (P=0.009). According to the results of this study, serum levels of FGF21 in diabetic patients was higher than the control group but these raised levels could not predict the presence of diabetic retinopathy.en
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/36357
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18358
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFibroblast growth factor 21en
dc.subjectType 2 diabetes mellitusen
dc.subjectDiabetic retinopathyen
dc.subject.ddc610
dc.titleThe relationship between serum levels of fibroblast growth factor 21 and diabetic retinopathyen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1
eldorado.secondarypublicationtrue

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