Effect of Syzygium cumini and Bauhinia forficata aqueous-leaf extracts on oxidative and mitochondrial parameters in vitro

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dc.contributor.authorEcker, Assis
dc.contributor.authorAraujo Vieira, Francielli
dc.contributor.authorde Souza Prestes, Alessandro
dc.contributor.authorMulling dos Santos, Matheus
dc.contributor.authorRamos, Angelica
dc.contributor.authorDias Ferreira, Rafael
dc.contributor.authorTeixeira de Macedo, Gabriel
dc.contributor.authorVargas Klimaczewski, Claudia
dc.contributor.authorLopes Seeger, Rodrigo
dc.contributor.authorTeixeira da Rocha, João Batista
dc.contributor.authorde Vargas Barbosa, Nilda B.
dc.date.accessioned2016-06-06T13:58:59Z
dc.date.available2016-06-06T13:58:59Z
dc.date.issued2015-11-27
dc.description.abstractAqueous-leaf extract of Syzygium cumini and Bauhinia forficata are traditionally used in the treatment of diabetes and cancer, especially in South America, Africa, and Asia. In this study, we analyzed the effects of these extracts on oxidative and mitochondrial parameters in vitro, as well as their protective activities against toxic agents. Phytochemical screenings of the extracts were carried out by HPLC analysis. The in vitro antioxidant capacities were compared by DPPH radical scavenging and Fe2+ chelating activities. Mitochondrial parameters observed were swelling, lipid peroxidation and dehydrogenase activity. The major chemical constituent of S. cumini was rutin. In B. forficata were predominant quercetin and gallic acid. S. cumini reduced DPPH radical more than B. forficata, and showed iron chelating activity at all tested concentrations, while B. forficata had not similar property. In mitochondria, high concentrations of B. forficata alone induced a decrease in mitochondrial dehydrogenase activity, but low concentrations of this extract prevented the effect induced by Fe2++H2O2. This was also observed with high concentrations of S. cumini. Both extracts partially prevented the lipid peroxidation induced by Fe2+/citrate. S. cumini was effective against mitochondrial swelling induced by Ca2+, while B. forficata alone induced swelling more than Ca2+. This study suggests that leaf extract of S. cumini might represent a useful therapeutic for the treatment of diseases related with mitochondrial dysfunctions. On the other hand, the consumption of B. forficata should be avoided because mitochondrial damages were observed, and this possibly may pose risk to human health.en
dc.identifier.doi10.17179/excli2015-576
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/2003/35061
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17109
dc.language.isoen
dc.relation.ispartofseriesEXCLI Journal;Vol. 14, 2015en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBauhinia forficateen
dc.subjectSyzygium cuminien
dc.subjectmitochondriaen
dc.subjectantioxidant propertiesen
dc.subject.ddc610
dc.titleEffect of Syzygium cumini and Bauhinia forficata aqueous-leaf extracts on oxidative and mitochondrial parameters in vitroen
dc.typeText
dc.type.publicationtypearticle
dcterms.accessRightsopen access
eldorado.dnb.zdberstkatid2132560-1

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